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Exam 16: Control of Gene Expression

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Question 21

Multiple Choice

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The TFIID complex is formed by

A) TATA-binding protein TBP and TAFs.
B) TATA-binding protein TBP, TAFs and RNA pol II.
C) TAFs and the core promoter.
D) TATA-binding protein and activators.

E) All of the above
F) A) and C)

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Question 22

Multiple Choice

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In eukaryotes, specific transcription factors have two distinct domains:

A) a DNA-binding domain and a RNA-binding domain.
B) a DNA-binding domain and an activation domain.
C) a DNA-binding domain and a repressor domain.
D) a DNA-binding domain and an enhancer domain.

E) C) and D)
F) B) and C)

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Question 23

Multiple Choice

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A protein that regulates transcription by binding to the operator is known as the

The p300/CBP (CREB-binding protein) proteins are histone acetyltransferases that help regulate the transcription of many genes.Based on this information you can conclude that these proteins

You are working to identify enhancer regions of a particular gene.The best place to look is

A site of negative genetic regulation where binding by repressor blocks transcription is the

Your research project involves the characterization of a recently identified transcription factor.As part of your project, you want to determine if this transcription factor binds directly to any of the general transcription factors.Unfortunately, you are having trouble expressing the full-length protein.What approach may help achieve your research goal?

The enzyme beta-galactosidase acts on lactose to form galactose.In turn, the presence of galactose leads to expression of the enzymes responsible for the metabolism of galactose.In this case, lactose is serving as a carbon source and as a(n)

The binding of TFIID is followed by the binding of a number of other general transcription factors.The correct order of binding of these factors would be

Certain proteins can bind to specific DNA regulatory sequences by entering

The progesterone receptor (PR) is a steroid hormone receptor and transcription factor.The protein SRC-1, which does not bind DNA by itself, can bind to PR and increase expression of genes regulated by PR.Based on this information, SRC-1 is best described as a(n)

A site at the 5' end of a gene where RNA polymerase attaches to initiate transcription is called a(n) .

The gene encoding apolipoprotein B exists in two isoforms, APOB100 and APOB48.These two forms are produced as a result of

The maintenance of a constant environment in a cell is called __________.

Eukaryotic cell mRNA transcripts can remain in the cell for hours because they are

In your research, you have discovered that Protein X is often ubiquitinated in people with a certain disease.What would you predict about levels of Protein X in these patients?

If a strain of bacteria had a mutation that blocked expression of the lac repressor, what would you expect as a result?

You are studying regulation of a prokaryotic operon.Experiments show that expression of the operon is increased when levels of biosynthetic product from that pathway are low.Based on this information, what is a likely mode of regulation?

You lead a research team challenged with the task of creating a regulatory protein able to shut off transcription of a particular gene.You focus your design around a binding site called an operator that is associated with the promotor.The physical location of the operator most likely to affect transcription would be

One of the DNA-binding motifs in many eukaryotic organisms that contains a nearly identical sequence of 60 amino acids is known as the