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What do all hormones have in common?


A) They are made from amino acids.
B) They are bound to transport molecules in the blood.
C) They bind to and interact with a receptor on or in the target cell.
D) They use the second messenger mechanism to control the target cell.
E) They are all lipid-soluble.

F) A) and E)
G) A) and B)

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David has been feeling tired lately, and after having blood work completed, it shows elevated TSH, low iodine, and low thyroid hormone levels. Predict the possible cause from the choices below.


A) David could possibly have a thyroid tumor.
B) David may have iodine deficiency that is causing his thyroid to produce too little thyroid hormone.
C) David could have a pituitary gland tumor.
D) Too little information is given to determine the cause.

E) C) and D)
F) A) and B)

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Which of the following is a regulatory protein associated with membrane-bound receptor molecules?


A) ATP
B) calcium
C) M protein
D) G protein
E) DNA

F) All of the above
G) A) and D)

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After a meal, blood glucose levels rise and stimulate the release of insulin. What type of stimulation is this example?


A) humoral
B) neural
C) hormonal
D) hypothalamic

E) All of the above
F) None of the above

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Consider the following events in the nuclear receptor model: (1) Hormone receptor complex binds to DNA. (2) Messenger RNA directs synthesis of specific proteins. (3) Hormone binds to receptors in the nucleus (sometimes in the cytoplasm) (4) Messenger RNA synthesis is activated. (5) Synthesized proteins produce the response of the cell. Which of these events occurs in the nucleus?


A) 1, 3, 5
B) 1, 3, 4
C) 1, 2, 3
D) 3, 4, 5
E) All events occur in the nucleus.

F) C) and D)
G) All of the above

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An intercellular chemical signal that is produced by neurons but functions like a hormone would be called a


A) neuropathogen.
B) neurotransmitter.
C) neurocrine.
D) neurohormone.
E) neurosynthesizer.

F) A) and C)
G) A) and B)

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What type of chemical messenger stimulates the cell that originally secreted it?


A) paracrine
B) neurotransmitter
C) autocrine
D) endocrine

E) None of the above
F) A) and D)

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Lipid-soluble hormones can be more easily excreted once they have water-soluble molecules added to their structure in a process called


A) saponification.
B) amplitude-modulation.
C) conjugation.
D) protein-binding.

E) All of the above
F) A) and D)

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All of the following characteristics of hormones except


A) Hormones alter activity in target cells
B) Hormones interact specifically with receptors
C) Hormones are stable in blood until arrival at target cells
D) Hormones interact with any cells in contact with bloodstream

E) A) and D)
F) B) and C)

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Secretion of one hormone by the action of another hormone is control by _______ stimuli.


A) hormonal
B) neural
C) humoral
D) visceral

E) None of the above
F) C) and D)

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Hormones with short half-lives


A) are usually lipid-soluble.
B) are maintained at relatively constant levels.
C) have concentrations that increase slowly.
D) regulate activities of delayed onset and long duration.
E) regulate activities of rapid onset and short duration.

F) B) and E)
G) B) and C)

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The half-life of a hormone allows one to determine


A) the rate of hormone secretion.
B) the identity of a hormone.
C) the rate at which hormones are eliminated from the body.
D) the rate of action of a hormone.
E) the rate of travel through the blood to a target.

F) A) and D)
G) A) and E)

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Which chemical type of hormone has a longer half-life?


A) lipid-soluble
B) protein
C) water-soluble
D) amino acid derivative

E) C) and D)
F) B) and C)

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A water-soluble hormone binds to its receptor on the plasma membrane. Arrange the events that follow in correct sequence. (1) alpha subunit-GTP complex alters cell activity (2) GTP binds to the alpha subunit replacing GDP (3) G-protein subunits separate from the receptor (4) alpha subunit separates from other two subunits (5) G-protein subunits bind to the receptor


A) 5, 2, 3, 4, 1
B) 4, 2, 1, 3, 5
C) 5, 2, 1, 4, 3
D) 5, 4, 2, 1, 3
E) 3, 4, 1, 2, 5

F) C) and E)
G) A) and E)

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All of the following chemical messengers may be listed in multiple functional classes except


A) Eicosanoids
B) Epinephrine
C) Prostaglandins
D) Acetylcholine

E) A) and C)
F) All of the above

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Match the chemical signal with the appropriate description. -paracrine


A) chemicals produced by neurons that function as hormones
B) chemicals that act locally on nearby cells
C) chemical secreted by presynaptic terminal
D) influences same cell type from which it is secreted
E) chemical secreted into blood by specialized cells; travels some distance to target tissues

F) A) and B)
G) A) and E)

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Parathyroid hormone is released when blood calcium levels decrease. This is an example of control by __________ stimuli.


A) hormonal
B) neural
C) humoral
D) visceral

E) None of the above
F) A) and C)

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All of the following are water-soluble hormones except


A) growth hormone
B) insulin
C) thyrotropin-releasing hormone
D) thyroid-stimulating hormone
E) thyroid hormone

F) C) and E)
G) A) and B)

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Which of the following events occurs last?


A) IP3 (inositol triphosphate) is produced.
B) Epinephrine combines with membrane-bound receptor on smooth muscle cell.
C) Calmodulin binds to the enzyme that phosphorylates myosin and cross-bridges form.
D) IP3 stimulates Ca2+ release from the endoplasmic reticulum.
E) Ca2+ binds with calmodulin.

F) A) and C)
G) B) and D)

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In some forms of diabetes, an insensitivity to insulin seems to be present. This insensitivity could be the result of


A) up-regulation.
B) over-regulation.
C) down-regulation.
D) a lack of regulation.
E) modulation.

F) D) and E)
G) B) and D)

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