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IgA antibodies are involved in innate immunity.

A) True
B) False

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Which of the following statements about antibody-mediated immunity is CORRECT?


A) It primarily defends against viruses that have already infected cells.
B) It is responsible for transplant tissue rejection.
C) It protects the body against cells that become cancerous.
D) It defends against parasites,bacteria,and viruses.
E) It primarily defends against bacteria that have already infected cells.

F) A) and E)
G) A) and C)

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All of the following are components of nonspecific immunity EXCEPT


A) skin.
B) phagocytes.
C) complement.
D) lysozyme.
E) B cells.

F) A) and D)
G) D) and E)

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Strategies to fight HIV include


A) inhibition of the reverse transcriptase enzyme.
B) inhibition of virus assembly.
C) prevention of HIV entering healthy cells.
D) prevention of other infections.
E) a combination of all of the abovE.

F) All of the above
G) B) and D)

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During the inflammatory response,dilation of blood vessels is caused by


A) nitric oxide.
B) histamine.
C) cytokines.
D) phagocytes.
E) both histamine and nitric oxidE.

F) B) and D)
G) A) and E)

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Which of the following is true of both T cells and B cells?


A) They produce effector cells against specific pathogens.
B) They are produced from stem cells of the lymphatic system.
C) They can attack and destroy invading pathogens.
D) They typically have a short life span.
E) All of these statements are truE.

F) C) and D)
G) None of the above

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E

Which of the following is NOT involved in nonspecific defenses?


A) natural killer cells
B) monocytes
C) neutrophils
D) mast cells
E) B cells

F) A) and C)
G) All of the above

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Recent research has shown that anti-inflammatory drugs can impair immune response to a vaccination.This makes sense since __________ participate in the inflammation response,and also act as APCs to present antigens to __________ that in turn activate __________ which produce antibodies.


A) macrophages;cytotoxic T cells;helper T cells
B) mast cells;helper T cells;macrophages
C) neutrophils;cytotoxic T cells;B cells
D) macrophages;helper T cells;B cells

E) A) and B)
F) All of the above

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Phagocytosis is a process in which a cell


A) takes in foreign particles and destroys them.
B) creates molecules and then excretes them.
C) lyses itself.
D) merges with another cell forming antibodies.
E) adheres to another cell.

F) B) and C)
G) None of the above

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The allergic response is primarily mediated by _____ antibodies.


A) IgG
B) IgM
C) IgA
D) IgE
E) IgD

F) C) and D)
G) A) and E)

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Generally speaking,vaccinations are effective in combating future infections because they induce the production of


A) helper T cells.
B) neutrophils.
C) prostaglandins.
D) mutations in the host genome.
E) memory cells.

F) B) and D)
G) C) and E)

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HIV infection and the subsequent destruction of which cell type is most devastating to overall immune system function?


A) cytotoxic T cells
B) memory B cells
C) helper T cells
D) monocytes
E) natural killer cells

F) A) and C)
G) A) and E)

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Which of the following is NOT an autoimmune disease?


A) multiple sclerosis
B) type I diabetes
C) rheumatoid arthritis
D) HIV
E) All of these conditions are autoimmune diseases.

F) A) and B)
G) A) and E)

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D

The protection provided through transfer of antibodies from mother to fetus is an example of


A) active immunity.
B) passive immunity.
C) cell-mediated immunity.
D) clonal selection.
E) autoimmunity.

F) B) and C)
G) A) and C)

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Most innate immune responses rely on


A) recognition of specific antigens.
B) pathogens being engulfed and destroyed.
C) plasma cells to secrete antibodies.
D) IgM antibodies.
E) clonal selection to replicate specific lymphocytes.

F) C) and D)
G) A) and D)

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You are trying to develop a new anti-inflammatory medication.Which of the following would be a possible approach?


A) suppressing cytokine release
B) blocking vasodilation
C) preventing leukocyte movement through the capillary wall
D) suppressing the release of nitric oxide from endothelial cells
E) All of these approaches would have an anti-inflammatory effect.

F) A) and C)
G) A) and B)

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The membrane attack complex is involved in specific immune defense mechanisms.

A) True
B) False

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Recall Bruno Lemaitre's experiment on Toll protein in Drosophila.In a similar experiment,you wanted to test a single fruit fly for the presence of the Toll protein,so you prick it with a needle coated in fungal spores.The fly dies a week later.Which of the following statements is TRUE?


A) This is evidence that the Toll protein is present.
B) This is evidence that the Toll protein is not present.
C) The Toll protein is only found in humans.
D) This is inconclusive evidence.

E) A) and B)
F) None of the above

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D

Which of the following pairs is incorrectly matched?


A) macrophage;class II MHC protein
B) B cell;immunoglobulin
C) B cell;IL-2
D) helper T cell;CD4
E) cytotoxic T cell;CD8

F) A) and B)
G) B) and E)

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Antigens are


A) non-self proteins.
B) proteins on the surface of B-cell membranes.
C) proteins that consist of two light and two heavy chain polypeptide chains.
D) proteins on the surface of macrophage membranes.
E) proteins on the surface of T-cell membranes.

F) A) and E)
G) B) and D)

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